Genes controlling pancreas ontogeny

Genes controlling pancreas ontogeny.

The pancreas develops from two separate and independent endodermal primordia. The molecular events supporting the early morphological changes that give rise to the formation of the dorsal and ventral pancreatic buds result from coordinated responses to extrinsic and intrinsic signals. The extrinsic signals are involved in processes dictating whether progenitor cells remain as immature or as com...

Controlling the Ir genes.

Nuclear Genes Controlling Male Fertility.

In higher plants, the developmental programs of the male and female organs are substantially independent of each other and of the vegetative plant. This developmental independence permits the genetic dissection of fertility processes without impairing vegetative growth. Male fertility requires a number of coordinated developmental events. These include the formation, as part of the flower, of s...

Transcriptional Mechanisms Controlling miR-375 Gene Expression in the Pancreas

MicroRNAs (miRNAs) are a class of small non-coding RNAs that play an important role in mediating a broad and expanding range of biological activities. miR-375 is expressed selectively in the pancreas. We have previously shown that selective expression of miR-375 in pancreatic beta cells is controlled by transcriptional mechanisms operating through a TATA box-containing promoter. Expression of m...

Malaria Virulence Genes Controlling Expressionthrough Chromatin Modification

Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh...